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| Ubiquitination : Ubiquitin ligase E3 | |||||||||
| E3 | Species | Substrate | E2 | Description | |||||
| Ubr1 | S. cerevisiae | Ubc2/Rad6 | involved in N-term rule | ||||||
| Ubr2 | S. cerevisiae | homologous to | |||||||
| Rad18 | S. cerevisiae | Ubc2/Rad6 | DNA binding | ||||||
| Npi1/Rsp5 | S. cerevisiae | Fur4, RNA polII large subunit | essential, hect domain, homologous to Nedd-4 | ||||||
| Ufd4 | S. cerevisiae | hect domain, multi-ubiquitination, 170kD | |||||||
| Tom1 | S. cerevisiae | involved in G2/M progression, hect domain, 380kD | |||||||
| Pub1 | S. pombe | Cdc25 | homologous to Nedd-4 | ||||||
| p100 | rat | ||||||||
| HYD | Drospphila | ||||||||
| E6-AP | human | Ubc5 subfamily | hect domain, Angelman syndrome | ||||||
| Nedd-4 | mouse, human | UbcH5B family | hect domain, homologous to Pub1 | ||||||
| E3RS-IkBalpha | human | IkB alpha | UbcH5C | ||||||
| Cdc53 | S. cerevisiae | Sic1, Cln | |||||||
| Hct4 | S. pombe | ||||||||
| Hct5 | S. pombe | ||||||||
| APC | human, xenopus | M cyclin, Cut2, Pds1 | UbcP4 subfamily, Ubc family, UBC-x/E2-c | 20S complex including Cdc27, Cdc16 and Cdc23 | |||||
| SCF/Cdc53 complex | S. cerevisiae | Sic1, Cln | Cdc34 | ||||||