|
|||||||||
| RADs : S. cerevisiae | |||||||||
| S. cerevisiae | S. pombe | Human | Mw (kD) | Chromosome | Description | ||||
| Rad1 | rad16 | XPF/ERCC4 | 104 | 16p13.1-13.2 | NER, 5'-nicking enzyme | ||||
| Rad2 | XPG/ERCC5 | 133 | endnuclease, 3'-nicking enzyme | ||||||
| Rad3 | XPD/ERCC2 | 87 | 5'-3' helicase, TFIIH subunit | ||||||
| Rad4 | XPC | 106 | SSB | ||||||
| Rad5/rev2 | |||||||||
| Rad6/Ubc2 | UbcP2 | involved in ubiquitin conjugation | |||||||
| Rad7 | Nucleotide excision repair protein involved in G(sub)2 repair of inactive genes | ||||||||
| Rad9 | crb2? | BRCA1?? | BRCT, homologous to Brca1 and 53BP1 | ||||||
| Rad10 | ERCC1 | 31 | endnuclease | ||||||
| Rad14 | XPA | 31 | Zn finger, involved in nucleotide excision repair | ||||||
| Rad16 | Nucleotide excision repair protein with DNA helicase domain of Snf2p family | ||||||||
| Rad17 | rad1 | Hrad1 | 282a.a. | 5p13.2-13.3 | 3'-5' exonuclease, homologous to Ustilago maydis Rec1 | ||||
| Rad18 | DNA repair | ||||||||
| Rad23B | HHR23B | 43 | ubiquitin like motif | ||||||
| Rad24/rs1 | rad17 | RF-C | 4q13.3-21.2 | RF-C, homologous to RF-C, interacts with Hrad1 | |||||
| Rad25 /Ssl2 | XPB/ERCC3 | 89 | 3'-5' helicase, TFIIH subunit | ||||||
| Rad26 | CSB/ERCC6 | 168 | TCR, DNA helicase motif | ||||||
| Rad27/FEN1 | rad2 | Fen1 | 42 | flap endnuclease | |||||
| Rad28 | CSA/ERCC8 | 44 | TCR, WD-repeat, involved in the same pathway as Rad26p | ||||||
| Rad29 | |||||||||
| Rad30/DBH1 | XP-V/DNA pol eta | radiation sensitive, similar to S. cerevisiae REV1 | |||||||
| Rad50 | nucleotide binding protein, interacts and colocalizes with Mre11p and Xrs2p. | ||||||||
| Rad51 | Rad51Hs | RecA homolog, interacts with Rad52p and Rad55p; human Rad51p homolog interacts with Brca2 | |||||||
| Rad52 | required for formation of synaptonema complex, interacts with Rad51p by two hybrid analysis | ||||||||
| Rad53/SPK1/MEC2 | cds1 | Chk2？ | 22q11 | protein kinase, mulicopy suppressor of pol alpha mutant | |||||
| Rad54 | required for X-ray damage repair, mitotic and meiotic recombination | ||||||||
| Rad55 | RecA homolog (related to DMC1, RAD51, RAD57), interacts with Rad51p and Rad57p by two-hybrid | ||||||||
| Rad56 | . | ||||||||
| Rad57 | RecA homolog (similar to DMC1, RAD51, and RAD55), interacts with Rad 55p by two-hybrid | ||||||||
| Rad59 | involved in mitotic recombination, homologous to the Rad52 protein | ||||||||
| MEC1/ERS1 | rad3 | ATR | protein kinaase | ||||||
| DPB11 | rad4/cut5 | BRCT, homologous to XRCC1 | |||||||
| DDC1 | rad9 | Hrad9 | 11p13.1-13.2 | ||||||
| rad24 | 14-3-3 | ||||||||
| rad25 | 14-3-3 | ||||||||