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| DNA Replication : Initiation of DNA Replication | ||||||||||||
| Family name | S. cerevisiae | S. pombe | Human | Mw (kD) | Chromosome | Xenopus | Drosophila | Description | ||||
| ORC1 | ORC1 | orp1 | ORC1Hs | 1p32 | XORC1 | DmORC1 | ATP binding motif, ATPase act. | |||||
| ORC2 | ORC2 | orp2 | ORC2Hs | 2q33 | XORC2 | DmORC2 | ATP binding motif | |||||
| ORC3 | ORC3 | orp3 | ORC3Hs | XORC3 | DmORC3 | ATP binding motif | ||||||
| ORC4 | ORC4 | orp4 | ORC4Hs | 45 | XORC4 | DmORC4 | ATP binding motif | |||||
| ORC5 | ORC5 | orp5 | ORC5Hs | 7q22 | XORC5 | DmORC5 | ATP binding motif | |||||
| ORC6 | ORC6/AAP1 | orp6 | XORC6 | |||||||||
| CDC6 | CDC6 (513 a.a.) | cdc18 (577 a.a.) | CDC6Hs | ATP/GTP binding motif | ||||||||
| CDC45 | CDC45 | CDC45Hs | 566a.a. | 22q11.2 | ||||||||
| CDC7 | CDC7 (508 a.a.) | Hsk1 (508 a.a.) | CDC7Hs | 574 a.a. | xcdc7 | protein kinase catalytic subunit | ||||||
| Dbf4 | Dbf4 (695 a.a.) | Him1 (545 a.a.) | H37 | 674 a.a. | protein kinase regulatory subunit | |||||||
| MCM2 | MCM2 | nda1/cdc19 | MCM2/BG28 | xMCM2 (886 a.a.) | DmMCM2 | associates with Histone H3 | ||||||
| MCM3 | MCM3 | mcm3 | MCM3/P1 | XMCM3 (807 a.a.) | ||||||||
| MCM4 | CDC54 | cdc21 | MCM4/mcdc21 | Xcdc21 (858 a.a.) | Dpa | component of replicative helicase complex? | ||||||
| MCM5 | CDC46/MCM5 | nda4 | MCM5/mCDC46 | xMCM5 (735 a.a.) | DmCDC46 | |||||||
| MCM6 | - | mis5 | MCM6 | xMCM6 (821 a.a.) | component of replicative helicase complex? | |||||||
| MCM7 | CDC47/MIS1 | MCM7/P1.1 | xMCM7 (720 a.a.) | component of replicative helicase complex? | ||||||||
| MCM10 | MCM10/DNA43 | cdc23 | ||||||||||