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| Checkpoint : DNA Damage Checkpoint | ||||||||||
| S. cerevisiae | S.pombe | Human | Mw (kD) | Chromosome | Structure and Function | Description | ||||
| RAD9 | crb2 | BRCA1?? | BRCT domain | homologous to Brca1 and 53BP1 | ||||||
| RAD24 | rad17 | Hrad17 | 4q13.3-21.2 | RF-C related | homologous to RF-C, interacts with Hrad1 | |||||
| RAD17 | rad1 | Hrad1 | 282a.a. | 5p13.2-13.3 | 3'-5' exonuclease | homologous to Ustilago maydis Rec1 | ||||
| MEC3 | GTPase? | |||||||||
| MEC1/ESR1 | rad3 | ATR | protein kinase | homologous to PI3 kinase | ||||||
| TEL1 | ATM | 11q23 | protein kinase | homologous to PI3 kinase | ||||||
| RAD53/SPK1/MEC2/SAD1 | cds1 | Chk2？ | 22q11 | protein kinase | multicopy suppressor of pol alpha mut | |||||
| Dun1 | Chk2？ | protein kinase | ||||||||
| C-TAK1 | protein kinase | Cdc25C associated protein kinase | ||||||||
| CHK1? | chk1 | Chk1 | 11q24 | protein kinase | ||||||
| POL2 | cdc20 | Pol epsilon catalylic subunit | 12q24.3 | DNA polymerase | ||||||
| DPB11 | cut5/rad4? | BRCT domain | multicopy suppressor of dpb2 | |||||||
| RFC5 | . | RFC38? | RF-C | |||||||
| DDC1 | rad9 | Hrad9 | 11p13.1-13.2 | |||||||
| BMH1, BNH2? | rad24. rad25 | 14-3-3 | 14-3-3 | |||||||
| - | Hus1 | Hus1Hs | 7p13-p12 | associated with rad1p and rad9p | ||||||
| rad26 | ||||||||||