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| CDCs : S. cerevisiae | |||||||||||||||
| S. cerevisiae | S. pombe | Human | Xenopus | Drosophila | Description | ||||||||||
| CDC1 | protein that affects bud emergence, intrachromosomal recombination | ||||||||||||||
| CDC2/POL3 | DNA pol delta catalytic subunit | DNA polymerase delta | |||||||||||||
| CDC3 | GTPase (septin family), defective in cytokinesis | ||||||||||||||
| CDC4 | component of SCF, WD40-repeat/F-box、homologous to G protein β subunit | ||||||||||||||
| CDC5/PKX2 | plo1 | PLK (polo like kinase) | polo | protein kinase | |||||||||||
| CDC6 | cdc18 | CDC6Hs | involved in initiation of DNA replication | ||||||||||||
| CDC7 | Hsk1 | cdc7Hs | xcdc7 | protein kinase | |||||||||||
| CDC8 | Thymidylate kinase | ||||||||||||||
| CDC9 | DNA ligase I, 102kD | DNA ligase | |||||||||||||
| CDC10 | GTPase (septin family), defective in cytokinesis | ||||||||||||||
| CDC11 | GTPase (septin family), defective in cytokinesis | ||||||||||||||
| CDC12 | GTPase (septin family), defective in cytokinesis | ||||||||||||||
| CDC13 | binds to single-stranded TG1-3 telomere G-tails | ||||||||||||||
| CDC14 | soluble tyrosine-specific protein phosphatase | ||||||||||||||
| CDC15 | protein kinase | ||||||||||||||
| CDC16 | Cut9 | APC6/Cdc16Hs | APC6 (75-78kD) | component of APC, tetratrico peptide repeat, spindle fiber | |||||||||||
| CDC17/POL1 | DNA polymerase alpha | DNA pol alpha catalytic subunit | |||||||||||||
| CDC18 | cdc5ts like phenotype | ||||||||||||||
| CDC19/PYK1 | pyruvate kinase | pyruvate kinase | |||||||||||||
| CDC20 | Slp1 | WD-repeat, inhibited by interaction with Mad1, 2 and 3 | |||||||||||||
| CDC21/TMP1 | Thymidylate synthetase | ||||||||||||||
| CDC23 | APC8Hs | APC8 (66-69kD) | component of APC, tetratrico peptide repeat | ||||||||||||
| CDC24/CLS4 | cdc24Hs | Ca binding protein, genetic interaction with CDC42 | |||||||||||||
| CDC25 | Ras-GEP, regulatory protein of adenylate cyclase | ||||||||||||||
| CDC27 | Nuc2 | APC3/Cdc27Hs | APC3 (100-130kD) | component of APC, tetratrico peptide repeat, spindle fiber | |||||||||||
| CDC28 | cdc2 | cdc2Hs/cdk1 | protein kinase | ||||||||||||
| CDC30 | glucose-phosphate isomerase | ||||||||||||||
| CDC31 | Ca binding protein, involved in replication of spindle pole body | ||||||||||||||
| CDC32 | some cdc32ts suppress cdc51ts | ||||||||||||||
| CDC33 | eIF-4E | ||||||||||||||
| CDC34/Ubc3 | component of SCF, ubiquitinate phosphorylated Cln2 as a E2 | ||||||||||||||
| CDC35/CYR1 | adenylate cyclase, interacts with Ira1 | ||||||||||||||
| CDC36 | required for Start B in mitosis and for meiosis I spindle pole body separation | ||||||||||||||
| CDC37 | cdc28ts like phenotype | ||||||||||||||
| CDC39 | required for Start B in mitosis and spindle pole body separation at meiosis I | ||||||||||||||
| CDC40 | partial DNA replication, | ||||||||||||||
| CDC42 | Rho subfamily, genetic interaction with CDC24 and CDC43 | ||||||||||||||
| CDC43 | β subunit of prenyltransferase, genetic interaction with CDC42 | ||||||||||||||
| CDC44 | hRFC140, 128kD | DNA pol delta accsessory protein, large subunit of RFC | |||||||||||||
| CDC45 | CDC45Hs (22q11.2, 566a.a.) | involved in initiation of DNA replication, genetic interaction with CDC46 and CDC47 | |||||||||||||
| CDC46/MCM5 | nda4 | MCM5/mCDC46 | - | DmCDC46 | member of complex that acts at ARS's to initiate replication | ||||||||||
| CDC47/MIS1 | - | MCM7/P1.1 | - | - | essential for initiation of DNA replication | ||||||||||
| CDC48 | homologous to multimeric ATPase | ||||||||||||||
| CDC49 | small bud and small nuclei | ||||||||||||||
| CDC50 | small bud and small nuclei | ||||||||||||||
| CDC51 | large bud and undivided nuclei, suppressed by cdc32ts | ||||||||||||||
| CDC53 | component of SCF, similar phenotype of cdc4ts and cdc34 | ||||||||||||||
| CDC54 | cdc21 | MCM4/mcdc21 | Xcdc21 | Dpa | genetic interaction with cdc46 and cdc47 | ||||||||||
| CDC55 | protein phosphatase2A regulatory subunit beta | ||||||||||||||
| CDC60 | cytosolic leucyl tRNA synthetase | ||||||||||||||
| CDC63/RPT1 | defective in initiatin of translation | ||||||||||||||
| CDC65/DNA33 | arrested cell cycle before Start | ||||||||||||||
| CDC67 | arrested cell cycle before Start | ||||||||||||||
| CDC68/SPT16 | DUF | suppressed by multicopy of CLN2, interacts with DNA pol alpha | |||||||||||||
| CDC72/NMT1 | N-myristoyltransferase | ||||||||||||||
| CDC73 | |||||||||||||||