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| Repair : Base Excision Repair | |||||||||
| Genes/Protein | Function | Chromosome | Phenotype of KO mouse | ||||||
| UDG | Uracil DNA glycosylase | 12q23-24.1 | |||||||
| AAG/MPG | alkyl-adenine DNA glycosylase | 16p-ter | normal | ||||||
| TDG | Thymine(T:G)-missmatch DNA glycosylase | 12q24.1 | |||||||
| hMYH | Adenine DNA glycosylase (8-oxoguanine : Adenine) | 1p32.1-34.3 | |||||||
| hOGG1 | 8-oxo-guanine DNA glycosylase | 3p25 | |||||||
| hNTH1 | Thymine glycol DNA glycosylase | 16p13.2-13.3 | |||||||
| PARP | poly(ADP-ribose) polymerase | 1q41-42 | low weight, hypersensitive to gamma-ray | ||||||
| APEX/Ref1/HAP1/APE | 5'AP endnuclease, DNA 3'-repair diesterase | 14q11.2-12 | fetal-lethal at E5 | ||||||
| Pol beta | DNA polymerase | 8p11-12 | fetal-lethal at E10.5 | ||||||
| Pol delta catalytic subunit | DNA polymerase | 19q13.3-13.4 | |||||||
| Pol delta small subunit | DNA polymerase accessory protein | 7 | |||||||
| Pol epsilon catalytic subunit | DNA polymerase | 12q24.3 | |||||||
| Pol epsilon small subunit | DNA polymerase accessory protein | 14q21-22 | |||||||
| PCNA | DNA pol delta auxiliary protein, clamp | 20p12 | |||||||
| FEN1 | 5'-flap endnuclease | 11q12-13 | |||||||
| XRCC1 | LIG3 binding protein | 19q13.2 | |||||||
| LIG1 | DNA ligase | 19q13.2-13.3 | fetal-lethal at ~E6.5 | ||||||
| LIG3 | DNA ligase | 17q11.2-12 | fetal-lethal at ~E11.5 | ||||||